Computational Mechanobiology


Maria J. Ledesma-Carbayo, Universidad Politecnica de Madrid, España
Arrate Munoz-Barrutia, Universidad Carlos III de Madrid, España


  1. Juan Carlo del Alamo, University of California San Diego, USA
  2. Kristin Branson, HHMI Janelia Research Campus, USA
  3. Gaudenz Danuser, UT Southwestern Medical Center, USA
  4. Jean Christophe Olivo-Marin, Institute Pasteur, France


Mechanobiology is an emerging field of science at the interface of biology and engineering that focuses on how physical forces and changes in the mechanical properties of the cells and tissues contributed to development, cell differentiation, physiology, and disease. Image-based multi-physics computational methods contribute to the construction of theoretical models that make it possible to understand the complexity of the constitutive behaviors of biological tissues in parallel to the cell response. These computational methods also play a key role in the image processing of the biological systems in particular at the cellular level to understand essential biology function such as mechano-sensing and mechano-transduction – the molecular mechanisms by which cells sense and respond to mechanical signals. The purpose of the special session is to have researchers working in this frontier between biology and engineering to share their experimental and theoretical efforts on computational mechanobiology that are transforming our understanding of what health and disease means.