Submission Title
Simulated dynamics of intracellular-extracellular potassium in a pathological astrocyte.
Abstract
The image represents a set of simulations detailing the dynamics of potassium handling by neocortex astrocytes under pathological conditions associated with Multiple Sclerosis (MS).
The image contains a series of plots over specific time intervals (0.0s to 10.0s). Each plot shows a cluster of points that represent individual astrocytes and the state of potassium dynamics, with the color indicating the concentration of extracellular potassium ([K+]) or intracellular potassium ([K-]) or the membrane potential (Vm). The plots show a more disorganized transition, indicating a dysregulation of potassium homeostasis, which is characteristic of MS-affected astrocytes. In this MS model, astrocytes show a pathologically altered potassium regulation, with a delayed and insufficient response to the same potassium influx. This deficiency became increasingly evident at later time points (5.0s and 10.0s), highlighting a compromised buffering capacity.
Authors
- Chrysoula Tsimperi (Aristotle University of Thessaloniki)
